PlateBlock™ is an ANIMAL-FREE and PROTEIN-free blocker for plastic surfaces (e.g. microtiter plates). This blocker is optimized for serological assays (antigen-down-assays).
For this assay format, it is essential that the blocking does not cover the epitope of the capture antigen and that the detector antibody does not cross react with the blocking surface.
In addition, some serum and plasma specimens from patients tend to detach single molecules from the dense blocking layer and replace them with other molecules (mostly antibodies of the patients). This results in high background levels if the specimen is not highly diluted. (Antibodies in low concentration could not be detected if the dilution of the sample is too high). Additionally, cross-linking between blocking and detector antibodies can be initiated by serum proteins.
PlateBlock™ is optimized to effectively prevent these kinds of substitution and background effects.
PlateBlock™ is ready-to use and available in bottle sizes of 125 mL and 500 mL.
For general laboratory use.
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| Brand | CANDOR Bioscience |
| Code | 112 125 |
Product Flyers and Application Guides
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Publications
CoViD-19-antibody-test-challenge
Interference and HAMA problems
IVD technology article
Long-term stabilization of assay components
Optimisation of assays: Interference in immunoassays recognize and avoid
SARS-CoV-2 antigen tests: safety for less than 5 cents per test
Specificity, positive predictive value and validation statistics in the context of CoViD-19
The appropriate blocker — A short overview
The right strategy saves much costs
