SmartBlock™ sets standards in the development of economically priced assays with good reliability e.g. for diagnostics, pharmaceutical research, pharmaceutical or biotechnological process control, food diagnostics, environmental diagnostics or research.
SmartBlock™ prevents non-specific and unwanted binding to surfaces, in many assays. By incubating with SmartBlock™, free spaces on the surface (of e.g. microtiter plate or western blotting membrane) are saturated by the components of SmartBlock™. Thus it prevents unwanted binding of the analyte or the detection antibody to the surface. As a result background can be avoided.
For many assays SmartBlock™ is an economical and useful alternative to BSA containing solutions.
Problems caused by BSA included in the blocker such as BSA-interactions and crossreactivities can be eliminated by using SmartBlock™.
Benefits of SmartBlock™
The blocking efficiency depends on different aspects. The better the efficiency of the blocker, the more reliable are the results of the assays (even with different specimens). It is important to have a complete saturation of the surface with a dense and gap-free layer. Any interaction of molecules of the blocking layer with the sample matrix should also be prevented. A good blocker can even fill small gaps and should be designed to minimize interactions.
SmartBlock™ is a candidate of a new class of blockers developed by CANDOR Bioscience. These blockers have chemical modifications which help to minimize interactions between the blocking layer and the sample matrix.
SmartBlock™ is based on peptides which were chemically modified. The molecules of these blockers can fill small gaps on the blocked surface e.g. between close-fitting coated capture antibodies. This enables a sufficient blocking for many assays.
SmartBlock™ is an economical modern blocker with a high blocking efficiency. The lot-to-lot consistency is very good. Thus SmartBlock™ is used even in the industrial production of immunodiagnostics.
To obtain an even better blocking effectivity compared to SmartBlock™, we recommend using The Blocking Solution. The Blocking Solution combines the advantages of blockers based on proteins with the good characteristics of modern chemically modified blockers. When reliability and very low coefficients of variation are important for your assay the use of The Blocking Solution is recommended.
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| Brand | CANDOR Bioscience |
| Code | 113 125 |
Product Flyers and Application Guides
Assay Optimizers
Assay Defender® Cat. No. #180
LowCross-Buffer® Cat. No. #100
LowCross-Buffer® Cat. No. #101, #102
LowCross-Buffer® Animal-free/Protein-free Cat. No. #300
Low-Cross-HRP® Cat. No. #200
LowCross® HRP-Stab Cat. No. #270
LowCross® HRP-Stab Animal-free/Protein-free Cat. No. #370
Sample Buffer Cat. No. #105, #106
Sample Buffer Animal-free/Protein-free Cat. No. #305
Covid-19 Inactivation and Dilution Buffer
SafetyTector™ S Cat. No. #400
Blockers
The Blocking Solution Cat. No. #110
BSA-Block Cat. No. #115
PlateBlock™ Cat. No. #112
SmartBlock™ Cat. No. #113
Stabilizers
Antibody Stabilizer TRIS Cat. No. #130
Antibody Stabilizer TRIS Animal-free/Protein-free Cat. No. #330
Antibody Stabilizer PBS Cat. No. #131
Antibody Stabilizer PBS Animal-free/Protein-free Cat. No. #331
AP-Protector® Cat. No. #235
Liquid Plate Sealer® Cat. No. #160
Liquid Plate Sealer® Animal-free Cat. No. #163
HRP-Protector™ Cat. No. #222
HRP-Protector™ Animal-free/Protein-free Cat. No. #322
Standard Buffers (ready-made)
Coating Buffer pH 7.4 Cat. No. #120
Coating Buffer pH 9.6 Cat. No. #121
Stripping Buffer Cat. No. #150
Washing Buffer PBS Cat. No. #140
Washing Buffer PBS IHC Cat. No. #141
Washing Buffer TRIS Cat. No. #145
Washing Buffer TRIS IHC Cat. No. #146
Publications
CoViD-19-antibody-test-challenge
Interference and HAMA problems
IVD technology article
Long-term stabilization of assay components
Optimisation of assays: Interference in immunoassays recognize and avoid
SARS-CoV-2 antigen tests: safety for less than 5 cents per test
Specificity, positive predictive value and validation statistics in the context of CoViD-19
The appropriate blocker — A short overview
The right strategy saves much costs
